Negative regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRI3BP, NCKAP1L, and SLC25A33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRI3BP grouped by Negative regulation of autophagy of mitochondrion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BRI3BP →	+0.949	+0.217	<.001	.005	3	5
BLOOD_Myeloma	NCKAP1L →	+3.118	+0.333	.009	.003	3	4
BONE	SLC25A33 →	+0.910	+0.224	.004	.002	3	4
OESOPHAGUS	TNFAIP3 →	-1.738	-0.183	.002	.001	2	5
OESOPHAGUS	MST1R →	-1.606	-0.161	<.001	.001	3	4
URINARY_TRACT	SLC16A3 →	-1.766	-0.375	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRI3BP by Negative regulation of autophagy of mitochondrion activity — BLOOD_Myeloma

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