Regulation of autophagy of mitochondrion

Across TCGA patient cohorts, RNA activity of the Regulation of autophagy of mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASKIN1_S1257, PRAG1_S745, and ARFGAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagy of mitochondrion activity versus CASKIN1_S1257 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CASKIN1_S1257 →	+1.243	+0.050	.001	.008	3	5
HNSC	PRAG1_S745 →	-0.451	-0.043	.003	.003	3	5
GBM	ARFGAP3 →	-0.428	-0.053	<.001	<.001	3	5
GBM	DNAJC11 →	+0.310	+0.035	<.001	.002	3	4
BRCA	CDC27 →	-0.189	-0.017	<.001	.004	3	4
GBM	MADD_S818 →	+0.397	+0.042	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903146 vs CASKIN1_S1257 — LSCC

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