Regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVA1A, LGALS1, and SRPX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EVA1A grouped by Regulation of autophagy of mitochondrion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EVA1A →	-3.412	-0.144	<.001	.005	3	6
SKIN	LGALS1 →	-1.184	-0.218	<.001	<.001	2	6
OESOPHAGUS	SRPX →	-1.037	-0.165	.003	.005	3	4
OESOPHAGUS	SH3BGRL3 →	-0.884	-0.151	.004	.003	3	4
OESOPHAGUS	TUFM →	+0.683	+0.202	.001	<.001	3	4
OESOPHAGUS	COQ9 →	+0.533	+0.149	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EVA1A by Regulation of autophagy of mitochondrion activity — LUNG_SCLC

Explore this box plot interactively →