Regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROCC, PEX14, and CIC, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagy of mitochondrion activity versus CROCC in BONE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CROCC →	+1.794	+0.112	.001	<.001	3	18
STOMACH	PEX14 →	+0.801	+0.081	<.001	.001	3	16
STOMACH	CIC →	+1.238	+0.097	.005	<.001	3	15
URINARY_TRACT	TSC2 →	+1.234	+0.103	.004	.002	3	15
BONE	INTS11 →	+1.058	+0.086	<.001	.002	3	15
STOMACH	UBR4 →	+0.884	+0.081	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903146 vs CROCC — BONE

Explore this scatter interactively →