Regulation of autophagy of mitochondrion

Across TCGA cell cohorts, RNA activity of the Regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAICS, UBR7, and NUP107, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of autophagy of mitochondrion activity versus PAICS in PANCREAS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PAICS →	+0.815	+0.185	.001	.001	3	6
SKIN	UBR7 →	+0.775	+0.258	.001	.001	3	5
LARGE_INTESTINE	NUP107 →	+0.544	+0.099	.001	.006	3	5
LUNG_NSCLC_LUSC	KCTD3 →	+1.064	+0.345	<.001	.002	3	5
LARGE_INTESTINE	FANCD2 →	+0.612	+0.152	.005	.002	3	5
LUNG_NSCLC_LUSC	ABCB10 →	+1.602	+0.434	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903146 vs PAICS — PANCREAS

Explore this scatter interactively →