Regulation of actin filament-based movement

Across TCGA patient cohorts, RNA activity of the Regulation of actin filament-based movement pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA4, GPX7, and DSC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament-based movement activity versus LILRA4 in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LILRA4 →	-0.643	-0.767	.002	.006	3	6
HNSC	GPX7 →	-0.926	-0.925	<.001	.005	3	5
HNSC	DSC2 →	+1.143	+0.788	<.001	<.001	3	5
HNSC	SIGLEC7 →	-0.521	-0.822	.001	.005	3	5
OV	C3orf80 →	-0.971	-0.385	.001	.003	3	5
OV	TNFRSF9 →	-0.649	-0.395	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903115 vs LILRA4 — BRCA

Explore this scatter interactively →