Regulation of actin filament-based movement

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament-based movement pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDK2, GATD1, and RRM2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDK2 grouped by Regulation of actin filament-based movement-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDK2 →	-0.550	-1.037	.009	<.001	3	4
LUNG_SCLC	GATD1 →	+0.818	+0.924	.002	.007	3	4
SKIN	RRM2B →	-0.793	-0.721	.001	.003	3	4
BLOOD_Lymphoma	ENY2 →	-0.933	-1.677	<.001	.001	3	3
CNS	ARFGAP3 →	-0.756	-1.102	<.001	<.001	3	3
OESOPHAGUS	SRP54 →	-0.942	-1.136	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDK2 by Regulation of actin filament-based movement activity — STOMACH

Explore this box plot interactively →