Regulation of actin filament-based movement

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament-based movement pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL2, GALNT3, and TRIM29, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament-based movement activity versus GRHL2 in URINARY_TRACT (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GRHL2 →	+4.384	+0.508	.001	<.001	3	8
URINARY_TRACT	GALNT3 →	+3.461	+0.420	<.001	<.001	3	8
OESOPHAGUS	TRIM29 →	+3.517	+0.380	.003	.002	3	8
BREAST	PLSCR1 →	+2.371	+0.293	<.001	<.001	3	8
OVARY	MPZL2 →	+3.373	+0.429	<.001	<.001	3	8
BREAST	GPR87 →	+2.576	+0.276	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903115 vs GRHL2 — URINARY_TRACT

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