Regulation of mitochondrial transcription

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial transcription pathway is significantly associated with the drug response of multiple features, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CP466722, CAY10603, and CX-5461, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CP466722 grouped by Regulation of mitochondrial transcription-low versus -high activity in PANCREAS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CP466722 →	-0.639	-0.193	<.001	.009	3	5
STOMACH	CAY10603 →	-1.054	-0.173	.048	.021	3	5
SKIN	CX-5461 →	-1.085	-0.201	.001	.003	3	5
OESOPHAGUS	TL-1-85 →	-0.441	-0.180	.018	.019	3	5
OESOPHAGUS	PIK-93 →	-0.743	-0.205	.005	.007	3	5
BONE	Dactolisib →	-0.934	-0.253	.049	.026	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CP466722 by Regulation of mitochondrial transcription activity — PANCREAS

Explore this box plot interactively →