Regulation of mitochondrial transcription

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial transcription pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLK2, CHST11, and TNFAIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial transcription activity versus PLK2 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PLK2 →	+3.192	+0.355	.001	.007	3	4
KIDNEY	CHST11 →	-2.170	-0.542	.007	.008	3	4
OESOPHAGUS	TNFAIP1 →	+1.241	+0.317	.002	.003	3	4
SKIN	SYNE3 →	+1.287	+0.429	.003	<.001	3	4
OESOPHAGUS	TEAD1 →	+1.095	+0.274	.001	.001	3	3
OESOPHAGUS	OSTM1 →	+1.355	+0.264	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903108 vs PLK2 — OESOPHAGUS

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