Protein localization to condensed chromosome

Across TCGA patient cohorts, RNA activity of the Protein localization to condensed chromosome pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGK, C1orf112, and URB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to condensed chromosome activity versus POGK in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POGK →	+0.495	+0.325	.002	.005	3	6
LSCC	C1orf112 →	+0.638	+0.363	<.001	.001	3	6
LSCC	URB2 →	+0.610	+0.515	<.001	<.001	3	6
LSCC	DTL →	+1.041	+0.587	<.001	<.001	3	6
LSCC	B3GALNT2 →	+0.502	+0.469	<.001	<.001	3	6
BRCA	CDC25A →	+0.795	+0.557	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903083 vs POGK — HNSC

Explore this scatter interactively →