Protein localization to condensed chromosome

Across TCGA cell cohorts, RNA activity of the Protein localization to condensed chromosome pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BICDL1, CD59, and ZFHX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BICDL1 grouped by Protein localization to condensed chromosome-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BICDL1 →	+2.525	+0.106	.004	.003	3	5
LIVER	CD59 →	-1.892	-0.118	<.001	<.001	3	5
LUNG_SCLC	ZFHX2 →	+1.042	+0.174	.001	.001	3	5
BLOOD_Lymphoma	VCL →	-2.355	-0.292	<.001	.008	3	5
BREAST	CCDC120 →	+1.257	+0.124	<.001	.008	2	6
LIVER	FJX1 →	-3.306	-0.109	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BICDL1 by Protein localization to condensed chromosome activity — LIVER

Explore this box plot interactively →