Positive regulation of protein localization to plasma membrane

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TROAP, KIFC1, and FANCE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to plasma membrane activity versus TROAP in UCEC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TROAP →	-0.929	-0.191	<.001	<.001	3	6
UCEC	KIFC1 →	-0.971	-0.188	<.001	<.001	3	6
UCEC	FANCE →	-0.757	-0.173	<.001	.001	3	5
UCEC	E2F1 →	-0.921	-0.186	<.001	<.001	3	5
LUAD	FOXF1 →	+0.421	+0.177	.002	.001	3	5
UCEC	FOXM1 →	-0.877	-0.220	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903078 vs TROAP — UCEC

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