Positive regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NACC2, PSMC5, and STBD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NACC2 grouped by Positive regulation of protein localization to plasma membrane-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NACC2 →	-1.042	-0.644	<.001	.005	3	5
LUNG_SCLC	PSMC5 →	-0.709	-1.000	.005	.008	3	4
BLOOD_Leukemia	STBD1 →	-0.983	-0.870	<.001	.001	3	3
BREAST	PRICKLE2 →	-1.077	-0.542	<.001	.004	3	3
BREAST	C11orf24 →	-0.757	-0.845	.002	<.001	3	3
SOFT_TISSUE	C6orf201 →	-0.218	-1.080	.008	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NACC2 by Positive regulation of protein localization to plasma membrane activity — STOMACH

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