Positive regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO41, GIGYF1, and SLC25A33, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to plasma membrane activity versus FBXO41 in LUNG_NSCLC_LUAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FBXO41 →	-1.136	-0.245	.001	.001	3	6
OVARY	GIGYF1 →	-0.741	-0.182	.004	.002	3	6
LIVER	SLC25A33 →	-0.940	-0.233	<.001	.003	3	6
OVARY	TRMT10C →	-0.583	-0.181	.001	.002	2	7
SOFT_TISSUE	CIB1 →	+1.597	+0.229	.002	.005	3	6
LIVER	PSMB8 →	+4.374	+0.333	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903078 vs FBXO41 — LUNG_NSCLC_LUAD

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