Regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFDN, EPCAM, and OVOL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFDN grouped by Regulation of protein localization to plasma membrane-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AFDN →	+1.309	+0.203	.002	<.001	3	5
LUNG_SCLC	EPCAM →	+4.822	+0.261	.001	.009	3	5
LUNG_SCLC	OVOL2 →	+3.335	+0.264	<.001	.006	3	5
LUNG_SCLC	KRT19 →	+4.552	+0.288	<.001	.004	3	5
LUNG_SCLC	CDH1 →	+4.393	+0.245	<.001	.003	3	5
LUNG_SCLC	OFD1 →	+1.256	+0.313	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFDN by Regulation of protein localization to plasma membrane activity — OESOPHAGUS

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