Regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F2, WDCP, and MVP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to plasma membrane activity versus E2F2 in SOFT_TISSUE (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	E2F2 →	-1.581	-0.201	.003	.003	3	9
BLOOD_Leukemia	WDCP →	-0.854	-0.234	<.001	<.001	3	9
LIVER	MVP →	+3.330	+0.290	<.001	.002	3	9
BONE	ANKRD13B →	-1.995	-0.310	.005	.006	3	9
BONE	CSPG5 →	-3.304	-0.250	.002	.002	3	8
BONE	SFPQ →	-0.846	-0.307	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903076 vs E2F2 — SOFT_TISSUE

Explore this scatter interactively →