Regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB1, ITGA3, and SRSF11, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to plasma membrane activity versus ITGB1 in LUNG_NSCLC_LUSC (Pearson r = 0.85).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ITGB1 →	+2.497	+0.369	<.001	.007	3	12
BONE	ITGA3 →	+3.638	+0.265	.002	.003	3	12
LARGE_INTESTINE	SRSF11 →	-0.932	-0.195	.003	.001	3	10
SOFT_TISSUE	RRAS →	+2.055	+0.326	.001	.001	3	10
BONE	ANXA2 →	+2.100	+0.257	<.001	<.001	3	10
BONE	RTN4 →	+1.530	+0.237	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903076 vs ITGB1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →