Regulation of protein lipidation

Across TCGA patient cohorts, RNA activity of the Regulation of protein lipidation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAND1, SMARCE1, and THOC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein lipidation activity versus CAND1 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAND1 →	+0.140	+0.046	.004	<.001	3	5
LSCC	SMARCE1 →	+0.329	+0.065	<.001	<.001	3	5
HNSC	THOC5 →	+0.190	+0.071	.002	<.001	3	5
HNSC	ZNF638 →	+0.311	+0.095	<.001	<.001	3	5
HNSC	ZNF687 →	+0.326	+0.070	.001	.008	3	5
HNSC	CDK9 →	+0.191	+0.073	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903059 vs CAND1 — BRCA

Explore this scatter interactively →