Regulation of protein lipidation

Across TCGA cell cohorts, RNA activity of the Regulation of protein lipidation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3GAP2, RB1CC1, and ULK1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB3GAP2 grouped by Regulation of protein lipidation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB3GAP2 →	-0.324	-1.572	.009	.001	3	11
OVARY	RB1CC1 →	-0.256	-1.068	<.001	.003	3	8
PANCREAS	ULK1 →	-0.122	-1.241	<.001	<.001	3	8
LIVER	DBI →	-0.430	-1.518	.008	.006	2	8
LUNG_NSCLC_LUSC	KEAP1 →	-0.308	-1.201	.009	.003	3	6
STOMACH	SSX3 →	+0.137	+1.018	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB3GAP2 by Regulation of protein lipidation activity — BONE

Explore this box plot interactively →