Regulation of protein lipidation

Across TCGA cell cohorts, RNA activity of the Regulation of protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBX2, TWF2, and B3GLCT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBX2 grouped by Regulation of protein lipidation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GBX2 →	-1.538	-0.912	.002	.001	3	4
LUNG_SCLC	TWF2 →	-0.938	-0.949	<.001	<.001	3	4
BLOOD_Lymphoma	B3GLCT →	-1.179	-0.465	.007	.006	3	4
BLOOD_Myeloma	TRAF3IP3 →	+2.546	+1.832	.005	.003	3	4
LARGE_INTESTINE	RPL3 →	+0.584	+0.795	.009	.008	2	5
BONE	HOXA1 →	-1.790	-1.167	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBX2 by Regulation of protein lipidation activity — LUNG_SCLC

Explore this box plot interactively →