Regulation of protein lipidation

Across TCGA cell cohorts, RNA activity of the Regulation of protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F2R, CABLES1, and MINDY1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein lipidation activity versus F2R in CNS (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F2R →	-1.348	-0.747	.003	.004	3	5
UPPER_AERODIGESTIVE_TRACT	CABLES1 →	-0.779	-1.372	.007	.003	3	4
BREAST	MINDY1 →	+1.342	+1.186	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ANXA9 →	+1.622	+0.522	.001	.003	3	4
LUNG_NSCLC_LUAD	SLC15A2 →	+0.730	+0.585	.008	.007	3	4
LUNG_NSCLC_LUAD	ARRDC1 →	+1.029	+0.739	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903059 vs F2R — CNS

Explore this scatter interactively →