Positive regulation of extracellular matrix organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix organization pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPG, SLC10A3, and WARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPG grouped by Positive regulation of extracellular matrix organization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MPG →	-0.257	-0.126	.003	.002	3	5
UPPER_AERODIGESTIVE_TRACT	SLC10A3 →	-0.176	-0.122	<.001	.002	3	5
LARGE_INTESTINE	WARS2 →	+0.280	+0.089	.002	.007	3	5
BREAST	E2F5 →	+0.353	+0.151	<.001	<.001	3	5
LUNG_NSCLC_LUSC	NCKAP1 →	+0.341	+0.152	<.001	.007	3	4
SKIN	PPP2R5D →	+0.174	+0.125	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPG by Positive regulation of extracellular matrix organization activity — SKIN

Explore this box plot interactively →