Negative regulation of extracellular matrix organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of extracellular matrix organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, COL1A1, and SVIL_S467, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extracellular matrix organization activity versus VCAN in OV (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCAN →	+1.100	+0.093	<.001	<.001	3	9
COAD	COL1A1 →	+0.773	+0.077	<.001	<.001	3	9
GBM	SVIL_S467 →	+0.824	+0.076	.002	.003	3	9
OV	PDGFRB →	+0.555	+0.108	<.001	<.001	3	9
COAD	COL3A1 →	+0.692	+0.071	<.001	<.001	3	9
CCRCC	PCOLCE →	+0.787	+0.101	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903054 vs VCAN — OV

Explore this scatter interactively →