Negative regulation of extracellular matrix organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of extracellular matrix organization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, PALLD_S972, and ANTXR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extracellular matrix organization activity versus FAP in COAD (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAP →	+0.753	+0.182	<.001	<.001	3	8
BRCA	PALLD_S972 →	+1.017	+0.164	<.001	<.001	3	7
COAD	ANTXR1 →	+0.673	+0.318	<.001	<.001	3	6
HNSC	ANTXR1_S362 →	+0.562	+0.193	<.001	<.001	3	6
LSCC	PDGFRB →	+0.428	+0.198	<.001	<.001	3	6
COAD	GULP1 →	+0.715	+0.252	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903054 vs FAP — COAD

Explore this scatter interactively →