Negative regulation of extracellular matrix organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of extracellular matrix organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPP4, CFTR, and COBLL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extracellular matrix organization activity versus DPP4 in URINARY_TRACT (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DPP4 →	+6.033	+1.918	<.001	<.001	3	6
LIVER	CFTR →	+0.814	+1.764	<.001	.002	3	4
LIVER	COBLL1 →	+2.473	+2.364	.005	<.001	3	4
SKIN	SLC22A18 →	+0.877	+0.405	.008	.006	3	4
OESOPHAGUS	TMEM45B →	+5.218	+2.141	<.001	<.001	3	4
STOMACH	TIMM23 →	-0.915	-1.810	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903054 vs DPP4 — URINARY_TRACT

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