Regulation of extracellular matrix organization

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOD1, TRRAP, and SEPTIN8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOD1 grouped by Regulation of extracellular matrix organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NOD1 →	+0.731	+0.209	.001	.007	3	3
BLOOD_Leukemia	TRRAP →	+1.023	+0.431	<.001	<.001	3	3
OVARY	SEPTIN8 →	+0.834	+0.687	.003	.001	3	3
BLOOD_Leukemia	NDRG3 →	+0.952	+0.319	.001	.003	3	3
BLOOD_Leukemia	GPCPD1 →	-0.968	-0.313	.004	.006	3	3
BLOOD_Leukemia	PRUNE1 →	+0.855	+0.383	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOD1 by Regulation of extracellular matrix organization activity — OESOPHAGUS

Explore this box plot interactively →