Regulation of extracellular matrix organization

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC1, TMEM144, and LAMB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extracellular matrix organization activity versus LAMC1 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LAMC1 →	+2.561	+0.991	<.001	.007	3	6
BREAST	TMEM144 →	-1.603	-1.156	<.001	.001	3	5
SKIN	LAMB1 →	+1.286	+0.901	<.001	.001	3	5
SKIN	COL8A1 →	+3.562	+1.078	.002	.003	3	4
BREAST	AFTPH →	-0.630	-0.981	.002	.004	3	4
BREAST	GALNT2 →	+1.394	+1.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903053 vs LAMC1 — BREAST

Explore this scatter interactively →