Meiotic cell cycle process

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, E2F1, and TROAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle process activity versus MYBL2 in BRCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBL2 →	+1.454	+0.589	.004	.007	3	5
BRCA	E2F1 →	+2.206	+1.235	<.001	<.001	3	5
LUAD	TROAP →	+1.196	+1.205	<.001	<.001	3	5
BRCA	SCN7A →	-1.090	-0.890	<.001	.001	3	5
BRCA	SPARCL1 →	-1.613	-0.942	<.001	<.001	3	5
BRCA	FANCG →	+0.346	+0.699	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903046 vs MYBL2 — BRCA

Explore this scatter interactively →