Meiotic cell cycle process

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, ITLN1, and C1S, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Meiotic cell cycle process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RAB21 →	+0.146	+0.123	.004	.007	3	5
URINARY_TRACT	ITLN1 →	+0.245	+0.194	.001	.005	3	5
STOMACH	C1S →	+0.232	+0.171	.004	.006	3	5
BLOOD_Leukemia	TDRD5 →	+0.333	+0.231	.002	.003	3	4
KIDNEY	TBX1 →	+0.171	+0.165	<.001	.008	3	4
KIDNEY	UGT1A8 →	+0.234	+0.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Meiotic cell cycle process activity — OESOPHAGUS

Explore this box plot interactively →