Meiotic cell cycle process

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NARS2, IGDCC4, and AKR1E2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle process activity versus NARS2 in LUNG_SCLC (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NARS2 →	+1.264	+0.292	<.001	<.001	3	5
BONE	IGDCC4 →	+0.942	+0.115	<.001	.003	3	4
BLOOD_Leukemia	AKR1E2 →	-1.127	-0.144	.006	.004	3	4
BLOOD_Leukemia	SERTAD3 →	-0.544	-0.119	.006	.008	3	4
LUNG_SCLC	TXNDC16 →	+1.785	+0.293	<.001	.001	3	4
URINARY_TRACT	THEM4 →	-1.156	-0.134	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903046 vs NARS2 — LUNG_SCLC

Explore this scatter interactively →