Protein localization to membrane raft

Across TCGA patient cohorts, RNA activity of the Protein localization to membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR223HG, SLC46A2, and RFTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to membrane raft activity versus MIR223HG in PDAC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MIR223HG →	+0.676	+0.123	<.001	.001	3	5
LUAD	SLC46A2 →	+1.131	+0.141	<.001	<.001	3	4
GBM	RFTN1 →	+0.579	+0.142	<.001	.003	3	4
COAD	PHYHIP →	+0.618	+0.145	.001	<.001	3	4
OV	RAB37 →	+0.275	+0.138	.008	<.001	3	4
COAD	PDE1B →	+0.317	+0.123	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903044 vs MIR223HG — PDAC

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