Protein localization to membrane raft

Across TCGA cell cohorts, RNA activity of the Protein localization to membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLPP2, AGBL2, and GATAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLPP2 grouped by Protein localization to membrane raft-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PHLPP2 →	+0.905	+1.148	.002	.005	3	5
LUNG_NSCLC_LUAD	AGBL2 →	+0.642	+0.595	.004	.006	3	4
CNS	GATAD1 →	-0.531	-1.114	.002	<.001	3	4
LUNG_NSCLC_LUSC	ZNF566 →	+1.133	+1.345	.002	<.001	3	4
URINARY_TRACT	ZNF669 →	+0.802	+1.504	<.001	.005	3	4
BLOOD_Myeloma	BAG5 →	+0.572	+1.198	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLPP2 by Protein localization to membrane raft activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →