Protein localization to membrane raft

Across TCGA cell cohorts, RNA activity of the Protein localization to membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1B1, NME4, and SLC16A6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to membrane raft activity versus ATP1B1 in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATP1B1 →	+1.745	+1.068	.009	.002	3	7
CNS	NME4 →	-1.156	-0.439	.001	.005	3	5
SKIN	SLC16A6 →	-4.245	-1.074	.003	.005	3	5
LARGE_INTESTINE	POLR1E →	-0.783	-0.281	<.001	.002	3	5
LUNG_SCLC	ARSG →	-0.697	-0.501	.006	.004	3	4
SKIN	CHKA →	-1.329	-0.897	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903044 vs ATP1B1 — SKIN

Explore this scatter interactively →