Positive regulation of leukocyte cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JDP2, PCK2, and KBTBD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JDP2 grouped by Positive regulation of leukocyte cell-cell adhesion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	JDP2 →	+1.764	+0.125	<.001	.003	3	4
LARGE_INTESTINE	PCK2 →	+1.081	+0.131	.009	.001	3	3
LARGE_INTESTINE	KBTBD7 →	+1.047	+0.161	.002	.001	3	3
LARGE_INTESTINE	NIT1 →	+0.679	+0.169	.005	<.001	3	3
LARGE_INTESTINE	DENND1B →	+1.022	+0.138	.002	.001	3	3
LUNG_NSCLC_LUAD	TSGA13 →	-0.015	-0.106	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JDP2 by Positive regulation of leukocyte cell-cell adhesion activity — OESOPHAGUS

Explore this box plot interactively →