Positive regulation of leukocyte cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX11, AGPAT4, and GNG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte cell-cell adhesion activity versus STX11 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STX11 →	+2.400	+0.212	.002	.004	3	6
OVARY	AGPAT4 →	+2.119	+0.328	<.001	<.001	3	6
LUNG_NSCLC_LUSC	GNG2 →	+2.852	+0.207	.003	.002	3	6
LIVER	PML →	+1.530	+0.243	<.001	.003	3	5
OVARY	CAVIN3 →	+2.630	+0.237	<.001	<.001	3	5
STOMACH	LRRC8C →	+1.706	+0.222	.008	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903039 vs STX11 — BLOOD_Lymphoma

Explore this scatter interactively →