Negative regulation of leukocyte cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and RCSD1_S351, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte cell-cell adhesion activity versus RCSD1 in HNSC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.650	+0.064	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.910	+0.088	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.556	+0.053	<.001	<.001	3	10
GBM	SAMSN1 →	+0.587	+0.052	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+1.008	+0.055	<.001	<.001	3	10
OV	SASH3 →	+0.561	+0.045	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903038 vs RCSD1 — HNSC

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