Negative regulation of leukocyte cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSTB, FCGR2B, and FAM20A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte cell-cell adhesion activity versus CSTB in UCEC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSTB →	+0.743	+0.734	<.001	<.001	3	6
OV	FCGR2B →	+0.821	+0.817	.007	.008	3	6
UCEC	FAM20A →	+1.027	+0.744	.001	.007	2	6
BRCA	RNF175 →	+0.584	+0.775	<.001	<.001	3	5
COAD	SLC11A1 →	+0.615	+0.974	.006	<.001	2	6
OV	FCGR1A →	+0.752	+0.569	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903038 vs CSTB — UCEC

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