Negative regulation of leukocyte cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHFL, NFKBID, and EDEM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHFL grouped by Negative regulation of leukocyte cell-cell adhesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SHFL →	+1.311	+0.207	.002	<.001	3	5
BLOOD_Leukemia	NFKBID →	+0.919	+0.173	.001	<.001	3	5
OVARY	EDEM1 →	+0.694	+0.176	.007	.002	3	4
CNS	ACVR2B →	-0.980	-0.214	.002	<.001	3	4
CNS	MFSD1 →	+0.891	+0.166	<.001	<.001	3	4
CNS	FLOT2 →	-0.608	-0.197	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHFL by Negative regulation of leukocyte cell-cell adhesion activity — CNS

Explore this box plot interactively →