Negative regulation of leukocyte cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, WDR76, and EPCAM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte cell-cell adhesion activity versus CSNK1G2 in OVARY (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CSNK1G2 →	+0.563	+0.351	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	WDR76 →	+1.122	+0.266	.001	.002	3	6
BLOOD_Leukemia	EPCAM →	-1.704	-0.149	.004	.002	3	6
URINARY_TRACT	DSC2 →	-3.990	-0.716	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	MFAP1 →	+0.644	+0.269	.001	.001	3	6
BREAST	UQCRC1 →	+0.568	+0.196	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903038 vs CSNK1G2 — OVARY

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