Negative regulation of leukocyte cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB2, PSMB4, and PSMA3, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte cell-cell adhesion activity versus PSMB2 in URINARY_TRACT (Pearson r = 0.90).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PSMB2 →	+1.756	+0.723	<.001	<.001	3	18
URINARY_TRACT	PSMB4 →	+1.871	+0.604	<.001	<.001	3	18
LUNG_NSCLC_LUSC	PSMA3 →	+2.102	+0.531	<.001	.001	3	17
URINARY_TRACT	PSMA6 →	+2.107	+0.625	<.001	.002	3	17
URINARY_TRACT	PSME2 →	+3.232	+0.566	<.001	.003	3	17
LUNG_NSCLC_LUSC	PSMA2 →	+1.957	+0.531	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903038 vs PSMB2 — URINARY_TRACT

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