Positive regulation of response to wounding

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to wounding pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUSD2, TNS2, and TNS2_S120, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to wounding activity versus SUSD2 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SUSD2 →	+0.487	+0.055	<.001	.002	3	9
OV	TNS2 →	+0.479	+0.058	<.001	<.001	3	9
BRCA	TNS2_S120 →	+0.650	+0.052	<.001	<.001	3	9
UCEC	VCL →	+0.579	+0.083	<.001	<.001	3	9
OV	ZCCHC24 →	+1.035	+0.054	<.001	.001	3	9
UCEC	CLPX →	-0.300	-0.068	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903036 vs SUSD2 — CCRCC

Explore this scatter interactively →