Positive regulation of response to wounding

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, ACTA2, and CNN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to wounding activity versus MYL9 in UCEC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYL9 →	+1.473	+0.325	<.001	<.001	3	9
UCEC	ACTA2 →	+1.514	+0.288	.008	.001	3	9
UCEC	CNN1 →	+1.727	+0.221	.001	<.001	3	9
UCEC	ACTG2 →	+2.215	+0.286	.003	.001	3	9
UCEC	LMOD1 →	+1.762	+0.259	<.001	<.001	3	9
UCEC	MSRB3 →	+1.355	+0.379	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903036 vs MYL9 — UCEC

Explore this scatter interactively →