Positive regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICALL2, MT-ND6, and CENPBD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICALL2 grouped by Positive regulation of response to wounding-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MICALL2 →	-2.712	-1.255	<.001	.001	3	4
SOFT_TISSUE	MT-ND6 →	-2.574	-0.400	<.001	<.001	3	3
BLOOD_Myeloma	CENPBD1 →	+1.049	+1.274	<.001	.002	3	3
BLOOD_Myeloma	CDK10 →	+0.738	+1.030	.007	.002	3	3
URINARY_TRACT	MITD1 →	+0.661	+0.276	.001	.002	3	3
BLOOD_Leukemia	C1orf50 →	-0.620	-0.861	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICALL2 by Positive regulation of response to wounding activity — BLOOD_Leukemia

Explore this box plot interactively →