Positive regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, OCLN, and JUP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to wounding activity versus GPR176 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GPR176 →	+3.467	+0.568	<.001	.002	3	6
BONE	OCLN →	-2.453	-0.318	.004	.001	3	6
BLOOD_Myeloma	JUP →	-2.971	-0.413	.002	.004	3	6
PANCREAS	MARVELD2 →	-1.227	-0.283	.001	.002	3	6
PANCREAS	LNX1 →	-1.313	-0.285	.007	.001	3	6
LIVER	SACS →	+1.613	+0.476	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903036 vs GPR176 — LIVER

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