Negative regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNH3, BIRC6, and PTCD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNH3 grouped by Negative regulation of response to wounding-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KCNH3 →	+1.040	+1.386	.003	<.001	3	5
LARGE_INTESTINE	BIRC6 →	+0.421	+0.624	.003	.004	3	5
LARGE_INTESTINE	PTCD3 →	+0.583	+0.799	.002	.009	3	5
PANCREAS	PEX12 →	+0.614	+1.256	.002	<.001	3	4
KIDNEY	FBXL4 →	+0.691	+1.299	<.001	<.001	3	4
BREAST	PLEKHH3 →	+0.556	+0.583	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNH3 by Negative regulation of response to wounding activity — URINARY_TRACT

Explore this box plot interactively →