Negative regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to wounding pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRN4, TLR5, and PKN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STRN4 grouped by Negative regulation of response to wounding-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	STRN4 →	-0.656	-0.164	.001	.003	3	5
LUNG_SCLC	TLR5 →	+0.261	+0.106	<.001	<.001	3	5
CNS	PKN3 →	-0.241	-0.073	<.001	.007	3	5
LIVER	ITLN2 →	+0.403	+0.118	.001	<.001	3	4
OESOPHAGUS	PDE4DIPP2 →	+0.366	+0.076	<.001	.001	3	4
LUNG_NSCLC_LUAD	UCK1 →	-0.122	-0.067	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STRN4 by Negative regulation of response to wounding activity — BONE

Explore this box plot interactively →