Negative regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBPL9, RELT, and IL1RN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to wounding activity versus OSBPL9 in LUNG_NSCLC_LUSC (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OSBPL9 →	-0.974	-0.212	<.001	.008	3	4
LARGE_INTESTINE	RELT →	-0.741	-0.276	.009	.006	3	4
PANCREAS	IL1RN →	+2.268	+0.227	.001	.005	3	4
BLOOD_Lymphoma	PPRC1 →	-0.895	-0.159	<.001	.009	3	4
SKIN	TASP1 →	+0.620	+0.213	.001	<.001	3	4
LUNG_NSCLC_LUSC	GLIS3 →	-2.514	-0.209	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903035 vs OSBPL9 — LUNG_NSCLC_LUSC

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