Regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC10, PLEKHN1, and PRELID3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC10 grouped by Regulation of response to wounding-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNAJC10 →	-1.081	-1.073	.003	.002	3	4
SOFT_TISSUE	PLEKHN1 →	-1.532	-0.921	<.001	.008	3	4
KIDNEY	PRELID3B →	+0.633	+0.858	.006	.001	3	3
KIDNEY	SDCBP →	+1.030	+0.886	.001	<.001	3	3
KIDNEY	FMC1 →	+0.904	+0.949	.001	.004	3	3
SKIN	SPRY2 →	-0.822	-0.783	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC10 by Regulation of response to wounding activity — SOFT_TISSUE

Explore this box plot interactively →