Regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of response to wounding pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FEN1, SLC10A3, and TBC1D3P2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FEN1 grouped by Regulation of response to wounding-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FEN1 →	-0.266	-0.147	.005	<.001	3	7
BONE	SLC10A3 →	-0.300	-0.205	.002	.001	3	5
LUNG_SCLC	TBC1D3P2 →	-0.193	-0.113	.001	.004	3	5
LARGE_INTESTINE	MAGEC1 →	-0.189	-0.073	.006	.001	3	5
LUNG_NSCLC_LUAD	MUC5B →	-0.106	-0.060	.006	.008	3	5
BONE	PPP1R12A →	+0.345	+0.145	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FEN1 by Regulation of response to wounding activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →